James H Segars Selected Research

Leiomyoma (Uterine Fibroids)

10/2021	Simvastatin modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradation.
1/2021	Angiotensin-Converting Enzyme Inhibitors Reduce Uterine Fibroid Incidence in Hypertensive Women.
1/2021	A Phase I Clinical Trial to Assess Safety and Tolerability of Injectable Collagenase in Women with Symptomatic Uterine Fibroids.
1/2021	A-kinase anchoring protein 13 interacts with the vitamin D receptor to alter vitamin D-dependent gene activation in uterine leiomyoma cells.
1/2021	Mechanical stiffness augments ligand-dependent progesterone receptor B activation via MEK 1/2 and Rho/ROCK-dependent signaling pathways in uterine fibroid cells.
1/2021	Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids.
1/2021	S1P and activin A induce fibrotic phenotype in uterine fibroids: a promising target for antifibrotic therapy.
11/2020	Simvastatin ameliorates altered mechanotransduction in uterine leiomyoma cells.
11/2020	A systematic review of the psychosocial impact of fibroids before and after treatment.
1/2019	A-Kinase Anchoring Protein 13 (AKAP13) Augments Progesterone Signaling in Uterine Fibroid Cells.

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James H Segars Research Topics

Disease

33	Leiomyoma (Uterine Fibroids) 10/2021 - 08/2003
10	Neoplasms (Cancer) 01/2021 - 12/2003
6	Infertility (Sterility) 01/2022 - 12/2012
4	Inflammation (Inflammations) 06/2021 - 02/2009
4	Fibrosis (Cirrhosis) 01/2021 - 01/2014
3	Ovarian Hyperstimulation Syndrome 09/2012 - 01/2006
2	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/2015 - 11/2010
2	Infections 01/2014 - 02/2005
2	Obesity 12/2011 - 11/2010
1	Endometriosis 01/2022
1	Female Genital Diseases 12/2021
1	Hyperlipidemias (Hyperlipidemia) 10/2021
1	Human Influenza (Influenza) 06/2021
1	COVID-19 06/2021
1	Communicable Diseases (Infectious Diseases) 06/2021
1	Pneumonia (Pneumonitis) 06/2021
1	Respiratory Insufficiency (Respiratory Failure) 06/2021
1	Virus Diseases (Viral Diseases) 06/2021
1	Sepsis (Septicemia) 06/2021
1	Pain (Aches) 01/2021
1	Hypertension (High Blood Pressure) 01/2018
1	Amenorrhea 01/2018
1	Pre-Eclampsia (Preeclampsia) 01/2017
1	Fetal Growth Retardation (Intrauterine Growth Retardation) 03/2016
1	Fetal Death 03/2016
1	Infarction (Infarctions) 03/2016
1	Vitamin D Deficiency 03/2015
1	Leiomyosarcoma 01/2015
1	Metabolic Diseases (Metabolic Disease) 01/2015
1	Carcinogenesis 08/2014
1	Menorrhagia 12/2012

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 06/2021 - 08/2003
8	CollagenIBA 01/2021 - 07/2004
6	Messenger RNA (mRNA)IBA 01/2021 - 08/2003
4	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2022 - 01/2006
4	Hormones (Hormone)IBA 10/2021 - 11/2010
3	Progesterone Receptors (Progesterone Receptor)IBA 12/2021 - 01/2018
3	Pharmaceutical PreparationsIBA 10/2021 - 01/2015
3	Progesterone FDA LinkGeneric 01/2021 - 12/2012
3	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2021 - 12/2003
3	Vitamin D FDA LinkGeneric 01/2021 - 03/2015
3	PhytochemicalsIBA 11/2017 - 08/2014
3	Estradiol (Delestrogen)FDA LinkGeneric 09/2012 - 12/2003
2	SteroidsIBA 10/2021 - 06/2021
2	Estrogens (Estrogen)FDA Link 10/2021 - 07/2004
2	Simvastatin (Zocor)FDA LinkGeneric 10/2021 - 11/2020
2	LigandsIBA 01/2021 - 01/2019
2	Collagenases (Collagenase)FDA Link 01/2021 - 01/2021
2	A Kinase Anchor ProteinsIBA 01/2021 - 01/2019
2	ulipristal acetate FDA Link 01/2019 - 01/2018
2	Pravastatin (Pravachol)FDA LinkGeneric 01/2017 - 03/2016
2	Transforming Growth Factor beta3 (TGF beta 3)IBA 12/2009 - 07/2004
2	Transforming Growth Factor beta (TGF-beta)IBA 12/2009 - 08/2006
2	Leuprolide (Lupron)FDA LinkGeneric 11/2006 - 01/2006
2	ganirelix FDA Link 11/2006 - 01/2006
1	elagolixIBA 01/2022
1	Androgen Receptors (Androgen Receptor)IBA 12/2021
1	Dexamethasone (Maxidex)FDA LinkGeneric 06/2021
1	GlucocorticoidsIBA 06/2021
1	activin AIBA 01/2021
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2021
1	Microbial Collagenase (Clostridiopeptidase A)FDA Link 01/2021
1	TransferasesIBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	progesterone receptor BIBA 01/2021
1	Quinapril (Accupril)FDA LinkGeneric 01/2021
1	Nuclear Antigens (Extractable Nuclear Antigens)IBA 01/2021
1	Verteporfin (Visudyne)FDA Link 01/2021
1	Ramipril (Altace)FDA LinkGeneric 01/2021
1	Lisinopril (Prinivil)FDA LinkGeneric 01/2021
1	Angiotensin IIIBA 01/2021
1	nintedanibIBA 01/2021
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2021
1	Calcitriol Receptors (Calcitriol Receptor)IBA 01/2021
1	Calcitriol (Calcijex)FDA LinkGeneric 01/2021
1	Progestins (Progestagens)IBA 01/2021
1	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/2021
1	Collagen Type I (Type I Collagen)IBA 11/2020
1	rhoA GTP-Binding ProteinIBA 11/2020
1	IntegrinsIBA 11/2020
1	LuciferasesIBA 01/2019
1	CreatinineIBA 01/2018
1	ulipristalIBA 01/2018
1	CateninsIBA 02/2017
1	FibrinIBA 03/2016
1	attenuinIBA 01/2015
1	Therapeutic UsesIBA 08/2014
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2014
1	Proteoglycans (Proteoglycan)IBA 01/2014
1	Aromatase InhibitorsIBA 12/2012

Therapy/Procedure

12	Therapeutics 10/2021 - 10/2006
5	Hysterectomy 01/2021 - 08/2003
2	Transplantation 01/2021 - 06/2017
1	Injections 01/2021
1	Aftercare (After-Treatment) 11/2020
1	Contraception (Birth Control) 01/2015
1	Minimally Invasive Surgical Procedures 01/2015
1	Ultrasonic Surgical Procedures 06/2014
1	Uterine Artery Embolization 03/2014
1	Catheters 01/2014